Senior Director (QSP), Clinical Pharmacology & Pharmacometrics, Research Business Insights/Information Technology

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Role Overview Bristol Myers Squibb is seeking a strategic, scientifically grounded leader to serve as the Senior Director for Clinical Pharmacology & Pharmacometrics. This leader will partner deeply with Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, and Translational Medicine stakeholders to deliver the applications, modeling environments, workflow automation, and governed operational capabilities that support CPP work end to end—from quantitative preclinical-to-clinical bridging through clinical PK/PD, dose and regimen decisions, and submission-support outputs.

This role supports the quantitative CPP layer across Research and Development, including pharmacometric workflows, clinical PK/PD systems, modeling platforms, reporting automation, regulatory evidence generation, and the governed operational capabilities required to run these workflows at scale.

Reporting to the Vice President, Research Business Insights & Technology, this leader will operate as part of a unified BI&T leadership team and act as a trusted partner to Research and Development leadership. The role carries accountability for the reliability, fit-for-purpose evolution, and long-term scaling of the CPP technology stack and workflow ecosystem, while working in a highly matrixed model with scientific leaders, data teams, lab-platform teams, and regulatory-facing partners.

Mission & Impact

• Provide a scalable application and workflow backbone for CPP across preclinical-to-clinical translation, clinical PK/PD, dose selection, exposure-response, and model-informed development decisions

• Improve the speed, quality, reproducibility, traceability, and inspection-readiness of pharmacometrics and clinical pharmacology workflows

• Strengthen regulatory submissions through robust reporting, reusable quantitative evidence generation, and auditable outputs that support documents such as clinical pharmacology summaries and model-based appendices

• Enable governed automation of priority CPP workflows, including reporting, simulation, execution, review, and knowledge reuse

• Create a durable technology foundation for end-to-end CPP that can scale with pipeline demand and integrate cleanly across the broader Research and Development ecosystem

Sub-Areas in Scope

• Clinical pharmacology and pharmacometrics applications, including population PK, PK/PD, exposure-response, dose optimization, and model-informed decision support

• PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows

• Clinical PK/PD systems and operational tooling that support end-to-end CPP execution

• CPAR, Quarto-based or similar reporting automation, and submission-support workflows for quantitative regulatory deliverables

• Quantitative translational workflows that bridge preclinical and clinical evidence in support of CPP decision-making

• Workflow governance, audit trails, validation support, access controls, and inspection-ready operational practices for regulated quantitative environments

• AI-enabled and advanced analytics capabilities that improve CPP workflow efficiency, simulation, review, reporting, and knowledge reuse

• In partnership, but not sole ownership: translational labs, pathology, molecular and imaging lab workflows, CLIA-oriented lab operations, precision medicine diagnostics, and broad bioanalytical capabilities

Key Responsibilities

• Serve as the single BI&T point of accountability for CPP technology, applications, workflows, and support services end to end

• Partner across Research and Development to integrate CPP workflows with the scientific, data, and operational capabilities required for model-informed drug development

• Own clinical pharmacology and pharmacometrics applications, modeling environments, reporting workflows, and operational support for core CPP use cases

• Ensure operational excellence, reliability, governance, and continuous improvement across modeling environments, clinical PK/PD systems, reporting workflows, and submission-support applications

• Lead automation of priority CPP workflows, including model execution, reporting, simulation, traceability, review, and evidence reuse

• Support quantitative regulatory deliverables through fit-for-purpose tooling, reproducible workflows, and inspection-ready practices

• Partner with Unified Lab & Experimental Platforms, Target & Disease Biology, and In-Vivo & Non-Clinical Pharmacology where translational science, lab systems, diagnostics, biomarker workflows, or bioanalytical capabilities intersect with CPP needs

• Partner with the R&D Data organization on underlying data-product strategy, integration, and fit-for-purpose data access

• Lead and grow a team of scientific technologists, product leaders, and specialized engineers aligned to this domain

Required Experience & Qualifications

• Ph.D. in Pharmacometrics, Clinical Pharmacology, Pharmaceutical Sciences, Biostatistics, or related quantitative field

• 12+ years in pharmaceutical R&D with deep clinical pharmacology, pharmacometrics, and model-informed drug development experience

• Proven experience implementing or leading CPP applications, PBPK and QSP environments, clinical PK/PD systems, or quantitative workflow automation

• Demonstrated experience supporting regulatory submissions, quantitative reporting, and governed workflows in Development-facing settings

• Experience applying AI/ML or advanced automation to quantitative modeling, reporting, or regulated scientific workflows is preferred

• Director or Senior Director-level leadership experience; experience building and scaling a specialized scientific technology team is a strong differentiator

Critical Capabilities

• Scientific Depth in Clinical Pharmacology and Pharmacometrics — Deep credibility with quantitative scientists and domain leaders across CPP

• Strategic Partnership — Translates scientific and Development needs into practical, integrated technology and workflow solutions

• Operational Leadership — Builds reliable, scalable, inspection-ready environments and support models for critical quantitative workflows

• Regulatory Translation Capability — Understands how quantitative evidence is prepared, reported, reviewed, and used in regulatory settings

Leadership & Change Attributes

• Strong partnership with senior scientific, clinical, and regulatory leaders

• Comfort operating with regulatory and global Development stakeholders

• Ability to recruit, develop, and retain highly specialized quantitative talent in a competitive market

• Experience navigating matrixed organizations and building credibility quickly

• Commitment to building a collaborative, high-performing culture in a growing team

What Differentiates Top Candidates

• Experience as a clinical pharmacology or pharmacometrics technology leader inside a top-tier pharmaceutical R&D organization

• Track record of applications, workflows, or platforms that improved dose selection, quantitative decision-making, or regulatory execution in Development-facing settings

• Experience deploying workflow automation, AI-enabled capabilities, or advanced analytics in support of end-to-end CPP modeling, reporting, and decision-support operations

• Demonstrated success building a specialized function from foundational capability to scaled organizational value while operating through strong matrix partnerships

#LI-Hybrid

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Brisbane - CA - US: $252,640 - $306,137 Cambridge Crossing: $252,640 - $306,137 Princeton - NJ - US: $229,670 - $278,306 San Diego - CA - US: $252,640 - $306,137

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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R1605309 : Senior Director (QSP), Clinical Pharmacology & Pharmacometrics, Research Business Insights/Information Technology