Senior

Translational AI Engineer

Cambridge, United States · Hybrid

ROLE SUMMARY:

The technical engineering counterpart to AIDE’s applied workflow roles, embedded within the Research Unit to convert promising AI workflow concepts into durable, evaluated, and supportable systems that accelerate translational science. This position is focused less on discovering use cases and more on the gap that appears once a prototype needs to scale in a scientific setting. The role translates recurring needs from computational biology, immunology, and clinical teams into fit-for-purpose AI systems, including generative AI, agentic workflows, predictive models, foundation models, retrieval-augmented systems, and fine-tuned model architectures. It also builds the data, evaluation, integration, and deployment layers beneath those systems, ensuring that internal AI tools do not remain fragile scripts or demos.

The ideal candidate is a hands-on translational AI engineer who can move fluidly between scientific intent, model behavior, and production-quality infrastructure. They should be comfortable reading and hardening AI-assisted codebases, standing up ETL (Extract, Transform, and Load) and database foundations, implementing cloud deployment and CI/CD patterns, and building evaluation harnesses that expose scientific, clinical, and technical failure modes before tools move from alpha to beta. The distinguishing strength is translational engineering judgment: turning ambiguous scientific needs into reliable AI systems, tracing failures to their root cause, defining fit-for-purpose evaluation with scientific and clinical partners, and knowing when to build internally versus adopt a commercial AI tool. This is a role for someone who turns promising AI workflows into systems that scientific and clinical partners can trust, reuse, and improve.

ROLE RESPONSIBILITIES:

Design and build fit-for-purpose AI/ML systems for recurring scientific and clinical workflows, including hybrid RAG when grounding and domain context are required.
Take AI-assisted prototypes built across AIDE and Systems Immunology, identify their technical and scientific failure modes, and rebuild parts that need engineering before scaling for wider use.
Stand up lean data platform and ETL underneath these systems, in partnership with Digital, so tools do not “rot” into one-off scripts.
Own promotion of internal AI tools from alpha to beta, define what “production-ready” means for a given tool, and build the evaluation harness that proves it.
Establish and document the SOPs that help others build rigorously from day one, instead of discovering the gap after a tool is already widely used.
Rigorously evaluate commercial AI/ML and GenAI tools and vendors against a build-vs-buy bar, covering capability, cost, security, scientific fit, and workflow readiness to support go/no-go purchasing decisions.
Run evaluation loops that measure system quality against workflow-specific scientific or clinical benchmarks, using input from computational biologists, immunologists, biologists, and clinicians to drive model selection and iteration.
Distill what is learned into hardened primitives, reference architectures, and benchmark harnesses that scale across AIDE’s other tools and deployments.
Apply the same rigor to AI that any scientific or translational method would receive: fit-for-purpose evaluation, grounded outputs, documentation, guardrails, disclosure of model limitations, and human oversight.
Stay current on translational AI methods and infrastructure, including generative AI, agentic systems, predictive modeling, biological foundation models, retrieval and fine-tuning methods, and fit-for-purpose evaluation practices as they evolve.
Contribute to a culture in AIDE where rigor is expected rather than exceptional, including calling out your own failures before someone else must.
Build external presence by attending relevant conferences, publishing methods and evaluation results, and presenting materials that showcase the group’s technical approach and impact.

BASIC QUALIFICATIONS:

PhD with 1+ years of experience OR Master’s degree with 5+ years of software or ML engineering experience - OR Bachelors degree and 6 + years of experience and/or equivalent demonstrated experience shipping AI/ML systems for scientific applications.
Hands-on experience building AI/ML systems beyond prompt-wrapping, with depth in at least one modality such as generative AI, agentic workflows, predictive models, foundation models, hybrid RAG, or fine-tuned architectures.
Demonstrated ability to evaluate, debug, and harden AI-assisted (“vibe-coded”) codebases: read a prototype someone else wrote quickly with AI assistance, find its failure modes, and rebuild the parts that need real engineering.
Strong Python engineer fluent in modern AI/ML tools, including model APIs, prompt engineering, hybrid RAG, fine-tuning, predictive modeling, evaluation tooling, and frameworks such as PyTorch, HuggingFace, LangChain, or LlamaIndex.
In-depth database and ETL experience (Postgres or equivalent) - able to stand up the data platform underneath a system, not only call an API.
Fluency in cloud infrastructure and deployment: hands-on with AWS, GCP, or Azure, containerization, and CI/CD.
Sufficient immunology, biology, translational research, or clinical workflow literacy to understand the problems computational biologists, immunologists, biologists, and clinicians are trying to address.
Demonstrated build-vs-buy judgment: has recommended adopting a commercial tool over an internal build where that was the better answer and can explain the tradeoffs that drove the decision.
Demonstrated practice of building evaluation harnesses, error analysis, and hardening into systems from the start, with specific examples tied to scientific or clinical workflow requirements.
Experience delivering in environments where requirements shifted as the work was learned, including examples of deliberately slowing down when speed was about to become a production liability.

PREFERRED QUALIFICATIONS:

Has taken an internal tool from “someone vibe-coded this and it mostly works” to a hardened, evaluated system, and can tell that story with specifics, including what was broken.
Has built and shipped a fit-for-purpose AI/ML system over messy scientific or clinical data, such as an agentic workflow, predictive model, foundation model application, hybrid RAG system, or fine-tuned architecture.
Has run a real build-vs-buy evaluation against commercial AI/ML or GenAI tools where the decision held up over time.
Full-stack range beyond the model layer: TypeScript and React, or equivalent, for internal dashboards and visual analytics that make evaluation results and system behavior legible to scientists and leadership.
Experience in immunology, inflammation, or an adjacent therapeutic area within pharma or biotech R&D, or with multi-omics data (RNA-seq, proteomics, GWAS, spatial transcriptomics, single-cell).
Familiarity with biological foundation models such as scGPT, Geneformer, ESM, or AlphaFold, or their application to real immunology research problems.
Has built production enterprise software meeting real security, compliance, auditability, and uptime requirements, not just a working prototype.
Strong open-source or publication record, ideally touching applied ML systems, evaluation methodology, or computational immunology.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Additional Job Details:

Last date to apply is September 16, 2026
Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week.

The annual base salary for this position ranges from $139,100.00 to $231,900.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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