**Senior Scientist, Translational Proteomics, Mass Spectrometry**

**Gaithersburg, MD**

Are you a passionate and experienced scientist with a background in Mass
Spectrometry and Clinical Proteomics? If so, AstraZeneca is looking for you!
We are seeking a motivated individual to join our Translational Proteomics
team within our Cancer Biomarker Development (CBD) group. This is an exciting
opportunity to apply your expertise and make a significant impact on the
clinical development of oncology drugs with innovative biomarkers.

**Accountabilities:**

In this role, you will be responsible for developing and applying mass
spectrometry-based proteomics workflows for biomarker quantification in
clinical samples. This will accelerate the development of AZ’s oncology
medicines. Your duties will include designing and implementing GCP-compliant
targeted mass spectrometry assays for biomarker studies, processing clinical
samples for translational and clinical studies, operating high-resolution LC-
MS instruments, analyzing data, summarizing results, and presenting key
results internally and externally. You will also collaborate with
translational medicine and bioinformatics teams to develop protein biomarkers.

**Essential Skills/Experience:**

* Ph.D. in bioanalytical chemistry or related field with 0-3 years post-doctoral experience in quantitative mass spectrometry-based proteomics.
  * Extensive experience acquiring and analyzing quantitative mass spectrometry-based proteomic data.
  * Extensive hands-on experience with LC-MS instrumentation for operation, maintenance, troubleshooting, quality control, and standardization for proteomics workflows.
  * Experience with human biological sample preparation for quantitative LC-MS applications.
  * Proficient programming skills (R, Python) for advanced data analysis and visualization.
  * Experience in working independently and collaboratively, with strong communication skills.

**Desirable Skills/Experience:**

* Experience in targeted proteomics, PRM/SRM assay development and definition of limits of quantitation.
  * Experience working in a GLP/GCP-regulated environment.
  * Experience with liquid handling robotics.

At AstraZeneca, we are united in our vision to eliminate cancer as a cause of
death. We are pioneers in the field of Oncology, pushing the boundaries of
science to transform the lives of patients living with cancer. With one of the
broadest and deepest Oncology pipelines in the industry, we offer many
opportunities to work with new and novel drugs. We foster a culture of courage
and curiosity, where everyone is empowered to take smart risks, challenge the
norm, and learn from failures. We believe in growing together and providing a
place where everyone can have a voice. Join us in our mission to make big
paradigm shifts in treatment options and make a meaningful difference to
people and patients around the world.

**About Our Gaithersburg Oncology Hub**

The Gaithersburg site
([https://www.youtube.com/watch?v=GOvxXGjBd1w](https://www.youtube.com/watch?v=GOvxXGjBd1w))
employs more than 3,500 experts in our field and is only a short drive from
Washington, DC. Here, we play host to some of the most cutting-edge technology
and lab spaces, all designed to inspire collaboration and cross-functional
science. We are dedicated to creating a culture of inclusion and
collaboration.

The Gaithersburg campus offers a variety of amenities to help boost
productivity and help keep our employees happy and healthy. This includes a
fitness center, employee healthcare clinic, electric vehicle charging
stations, dry cleaning, full-service cafeteria, game rooms, community garden
and much more.

At AstraZeneca's Oncology R&D department, we push the boundaries of science to
change the practice of medicine and transform the lives of patients living
with cancer. We are a science, leading and decisive Oncology enterprise united
in our vision to eliminate cancer as a cause of death. With one of the
broadest and deepest Oncology pipelines in the industry, there are many
opportunities to work with new and novel drugs and help discover what's next.

We believe in growing together and providing a place where everyone can have a
voice. Ambitious and collaborative, we're optimistic in our ability to be
resilient and work together towards a cure.

Ready to make a difference? Apply today and join us in our mission to
eliminate cancer as a cause of death!

If you’re curious to know more, please contact Bobbi Poole, our Talent
Acquisition Partner.

**Closing Date: April 24 , 2024**

**Competitive remuneration and benefits apply**

We offer a competitive Total Reward program including a market driven base
salary, bonus and long term incentive. We have a generous paid time off
program and a comprehensive benefits package.

**Where can I find out more?**

**Our Social Media, Follow AstraZeneca on LinkedIn**[
https://www.linkedin.com/company/1603/](https://www.linkedin.com/company/1603/)

**Follow AstraZeneca on Facebook**[
https://www.facebook.com/astrazenecacareers/](https://www.facebook.com/astrazenecacareers/)

**Follow AstraZeneca on
Instagram**[**https://www.instagram.com/astrazeneca_careers/?hl=en**](https://www.instagram.com/astrazeneca_careers/?hl=en)

AstraZeneca embraces diversity and equality of opportunity. We are committed
to building an inclusive and diverse team representing all backgrounds, with
as wide a range of perspectives as possible, and harnessing industry-leading
skills. We believe that the more inclusive we are, the better our work will
be. We welcome and consider applications to join our team from all qualified
candidates, regardless of their characteristics. We follow all applicable laws
and regulations on non-discrimination in employment (and recruitment), as well
as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable
accommodation to participate in the job application or interview process, to
perform essential job functions, and to receive other benefits and privileges
of employment. Please contact us to request accommodation.

**Date Posted**

26-Mar-2024

**Closing Date**

23-Apr-2024Our mission is to build an inclusive and equitable environment. We
want people to feel they belong at AstraZeneca and Alexion, starting with our
recruitment process. We welcome and consider applications from all qualified
candidates, regardless of characteristics. We offer reasonable
adjustments/accommodations to help all candidates to perform at their best. If
you have a need for any adjustments/accommodations, please complete the
section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but
will consider requests for reasonable accommodations as required by applicable
law.



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AstraZeneca

AstraZeneca is seeking a Senior Scientist for our Translational Proteomics team in Gaithersburg, MD, focusing on mass spectrometry-based proteomics for oncology drug development. This role involves developing proteomics workflows, operating LC-MS instruments, and collaborating on biomarker development. Candidates should have a Ph.D. in bioanalytical chemistry or a related field, experience in quantitative proteomics, and proficiency in programming for data analysis.

Senior Scientist, Translational Proteomics, Mass Spectrometry

Summary